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Cellular Potts Model
Models
Built-in Examples
Cellular Potts Models
Differential Adhesion: Cell Sorting in Two Dimensions
Morpheus Model ID:
M0021
Glazier-Graner Model of cell sorting Introduction This model shows the original cellular Potts model (a.k.a. Glazier-Graner model) of cell sorting based on the Steinberg’s differential adhesion hypothesis. Figure 1.
F. Graner
,
J. A. Glazier
(Authors)
W. de Back
,
D. Jahn
(Contributors)
Morpheus at Recent & Upcoming Events
OpenVT Multicellular Modelling Workshop 2025
Diversity in simulation methods poses challenges in reproducibility, modularity, reusability, and integration within multi-scale simulation. This workshop …
Sun, 13 Jul 2025 09:30 -0600 — 17:00 -0600
Lister Centre, University of Alberta, Edmonton, Canada
Morpheus at Recent & Upcoming Events
OpenVT Reproducible Agent-Based Multicellular Model Competition 2025
This competition is designed to promote and support the development of multicellular models which follow
FAIR principles
Specifically, it recognizes recently published …
Mon, 31 Mar 2025
Virtual
Submit Your Model
Models
Published Models
Zebrafish
Robust Guidance by Followers
Morpheus Model ID:
M0008
Guidance-by-followers combined with one of several simple rule sets for integration of signals from multiple neighbors provides a robust mechanism for collective cell migration. Introduction Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor invasion.
R. Müller
,
A. Boutillon
,
D. Jahn
,
J. Starruß
,
N. B. David
,
L. Brusch
(Authors)
D. Jahn
(Contributor)
DOI:10.3389/fams.2023.1163583
Models
Published Models
Zebrafish
Beta Cell Turnover in Pancreatic Islet
Morpheus Model ID:
M2986
How is the right islet size established during zebrafish pancreas development? Introduction Beta cells in the developing pancreas of zebrafish divide rapidly between 5 and 30 days post fertilization (dpf) and additional beta cells are recruited to the islet.
M. N. Akhtar
,
A. Hnatiuk
,
L. Delgadillo-Silva
,
S. Geravandi
,
K. Sameith
,
S. Reinhardt
,
K. Bernhardt
,
S. P. Singh
,
K. Maedler
,
L. Brusch
,
N. Ninov
(Authors)
L. Brusch
,
D. Jahn
(Contributors)
Models
Published Models
Zebrafish
Neural Stem Cell Redivisions in Adult Zebrafish Telencephalon
Morpheus Model ID:
M2984
Introduction Whether individual stem cell divisions are coordinated or random is important for tissue morphogenesis, homeostasis and tumour growth. Lupperger et al. have analyzed the spatio-temporal division patterns of adult neural stem cells (NSC) in the zebrafish telencephalon.
V. Lupperger
,
C. Marr
,
P. Chapouton
(Authors)
V. Lupperger
,
L. Brusch
(Contributors)
DOI:10.1371/journal.pbio.3000708
Models
Published Models
Worm
Caenorhabditis elegans L1 Aggregation
Morpheus Model ID:
M7683
Introduction Larvae of the nematode Caenorhabditis elegans aggregate into clusters of several hundred moving individuals when starved during their first larval stage (see video below). Avery et al. proposed that starved larvae produce and respond chemotactically to two diffusible chemical signals, a short-range attractant and a longer range repellent.
L. Avery
,
B. Ingalls
,
C. Dumur
,
A. Artyukhin
(Authors)
L. Brusch
(Contributor)
DOI:10.1371/journal.pcbi.1009231
Models
Published Models
Principles
Single Genotype Circuit
Morpheus Model ID:
M2053
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Three Layer Circuit
Morpheus Model ID:
M2052
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Two Layer Circuit
Morpheus Model ID:
M2051
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
»
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